#1432 - Aubrey de Grey

Episode Timestamps

• 00:00:00

  Conversation with Unnamed Person on Human Aging

  • Discussion about beard grooming and aging.
  • Exploration of advancements in understanding human aging.
  • Explanation of aging as a consequence of damages from everyday functions.
• 00:01:49

  Aging and its Biological Consequences

  • Comparison of aging in living organisms to machine wear and tear.
  • Explanation of the accumulation of molecular and cellular changes in the body over time.
  • Discussion about differences in recovery from injuries and overall decline with age.
• 00:10:01

  Sensory Research Foundation's Dedication to Age Reversal

  • Focus on repairing all types of damage to reverse aging rather than just maintaining it.
  • Independence from government grants, relying solely on philanthropy for funding.
  • Emphasis on high-risk, high-reward research neglected by traditional funding sources.
• 00:13:14

  Private Sector's Growing Interest in Rejuvenation Medicine

  • Shift towards private investors supporting rejuvenation medicine projects.
  • Progress in stem cell therapies and synolytics for aging-related diseases like Parkinson's.
  • Increasing number of companies and initiatives dedicated to age-reversal research.
• 00:21:29

  Breakthrough in Stem Cell Research and Clinical Trials for Parkinson's Disease

  • Research on manipulating cells to desired outcomes, including stem cells, has been progressing rapidly
  • Specialists are optimistic about Parkinson's disease clinical trials, currently in phase one
  • Multiple groups worldwide focused on advancing stem cell therapies for various conditions
• 00:24:25

  Challenges and Progress in Funding Biomedical Research for Aging

  • Historical lack of funding slowed down advancements in aging research
  • Increased investment opportunities have led to accelerated progress in research
  • Mindsets around aging as a natural process being challenged by biomedical advancements
• 00:32:29

  Leading the Crusade: Tale of Artifical Intelligence to Biology Transition

  • Became interested in making a difference from a young age, focused on improving humanity's quality and quantity of life
  • Transitioned from artificial intelligence research to biology after meeting a biologist spouse and realizing aging was neglected in research
  • Eureka moment in 2000, advocating for damage repair in biology field, encountering initial skepticism before gaining recognition
• 00:41:36

  Provoking Change: Overcoming Resistance and Intellectual Blinders

  • Constantly looking for overlooked solutions, frustrated by slow progress and irrational resistance in pursuit of aging research
  • Recognizes societal resistance to addressing physiological decline, empathetic towards those who struggle with the concept of aging and dying
  • Engaged in heated discussions with intellectuals, faced challenges in getting people to think about aging and its implications
• 00:44:18

  Hypnotist and Ageing Discussion

  • Hypnotist challenges a guy's ability to stop doing something
  • The guy provides a convincing explanation for failing the challenge
  • Discussion on aging and the pro-aging trance phenomenon
  • Arguments against aging and technological advancements
• 00:47:30

  Technological Solutions and Ocean Health

  • Technological solutions to increase the planet's carrying capacity
  • Progress in renewable energy and agriculture
  • Depletion of fish populations and the need for artificial fish
  • Optimism about the potential for environmental cleanup
• 00:56:24

  Impacts of Increased Lifespan on Global Economy and Policy

  • People expected to live longer resulting in changes in financial plans such as pension and insurance
  • Shift in public expectation requires policymakers to anticipate and estimate future changes
  • Prediction of rapid shift in public perception within 3-5 years due to significant progress in anti-aging technologies
• 00:57:34

  Anticipation of Rapid Policy Changes in Response to Aging Research

  • Expert opinions expected to align with positive outlook on anti-aging progress
  • Media influence on public opinion crucial in shifting policy focus towards anti-aging initiatives
  • Anticipated sudden shift in healthcare economics due to potential elimination of age-related diseases
• 01:08:49

  Future of Work and Basic Income

  • Economy shifting away from full employment model like during Industrial Revolution
  • Discussion on universal basic income as a possible solution
  • Concept of work being inexorably connected to society
  • Importance of education in addressing work boredom and fulfillment
• 01:12:36

  CRISPR and Genetic Engineering

  • Explanation of CRISPR technology and gene editing
  • Potential of gene therapy and stem cells in extending lifespan
  • Discussion on CRISPR application in altering DNA, limitations, and ethical concerns
• 01:20:14

  Stem Cell Therapy and Intravenous Treatment Benefits Experienced by 'Neil' and 'Mother'

  • Several fighters from the UFC have benefited from the treatment provided by Neil.
  • Mother, aged 73, initially skeptical, experienced pain relief and improved mobility after 6-8 months of treatment.
  • Three days of intravenous therapy showed visible signs of rejuvenation in Mother, making her look and feel younger.
• 01:22:41

  Risk and Benefits of Stem Cell Therapies with Focus on Cancer and Fasting

  • Stem cell therapies are still in experimental stages with potential benefits but also risks like cancer.
  • Fasting has shown potential benefits, especially in slowing down cancer's progression by reducing energy consumption.
  • Various fasting methods and calorie restriction mimetics are researched for health benefits but may not significantly impact longevity in humans.
• 01:31:33

  Discussion on Sensory Deprivation Tanks and Future Technological Breakthroughs

  • The speaker advocates using a sensory deprivation tank for relaxation.
  • Conversation touches on future breakthroughs in technology and extending human lifespan.
  • Challenges in combining multiple treatments to tackle aging are discussed.
• 01:35:23

  Optimism and Excitement for Future Technological Changes

  • The speaker expresses excitement about the rapid changes in technology and society.
  • Mentions being intrigued by extending lifespan and witnessing societal shifts.
  • Discusses how exponential changes in culture and lifestyle shape human history.