#1349 - David Sinclair
NaN minutesEpisode #1349
David Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. His new book "Lifespan: Why We Age And Why We Don't Have To" is now available.
Episodes with David Sinclair
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Episode Timestamps
David Sinclair - Exploring the Possibilities of Anti-aging with Joe Rogan
- Discussion on the potential of Metformin, DHEA, and human growth hormone to reverse biological age.
- Introduction to the Horvath clock, a new method of measuring aging using DNA modifications.
- Exploration of techniques to potentially reverse aging by a decade or more.
Revisiting Antioxidants and Exploring the Effects of Metformin on Physical Performance
- Analysis of the limitations of antioxidants in extending lifespan.
- Explanation of how resveratrol impacts the body's defenses against aging and disease.
- Insight into the strategy of pulsing metformin intake based on exercise and recovery days.
Metformin and Mitochondria Interactions
- Metformin interrupts energy production in the mitochondria
- Body responds by expanding the number of mitochondria
- Study revealed that metformin prevented the mitochondria from amplifying after exercise
Health Habits and Nutrition of Researchers
- Discussion on how some researchers neglect their own health habits
- Examples of researchers with poor dietary habits despite working on health-related topics
- Challenge of finding time for exercise due to work commitments
Justin Renn's Fight for the Pygmies in Congo
- Pygmies used to take drugs like clustered denium and weed to feel invincible
- Support for pygmies through Fight for the Forgotten Charity founded by Justin Renn
- Efforts to build wells for pygmies in Congo and organize benefits for them
Plight of Pygmies and Conservation Efforts
- Pygmies face challenges after being kicked off their land for conservation
- Discussion on rebuilding school for the Batua tribe and pygmies in Uganda
- Awareness on supporting pygmies through tourism and local initiatives
Survival Adventures with Les Stroud
- Les Stroud demonstrates true survival tactics amidst dangerous situations.
- Survives with limited resources while surrounded by lions.
- Highlights include using a propane-powered device to scare off predators.
Origins Journey in Africa
- Embarks on a 16-day journey through Kenya, Tanzania, and Uganda with family.
- Visits significant archaeological sites like Olduvai Gorge, where early human fossils were discovered.
- Reflects on the essence of human existence and ancient origins.
Discussion on Brad Pitt Zombie Movie Scene
- Brad Pitt zombie movie described where zombies pile on top of each other to climb a wall
- Soldiers shooting at the zombies as they try to climb the wall and infect people
- Reference to the novels by Max Brooks, son of Mel Brooks
Exploration of Human Origins, Stone Tools, and Longevity
- Discussion on human origins, oldest fossils, and stone tools found in Africa
- Mention of the discovery of stone tools in the United States dating back to 16,000 years ago
- Conversation about human lifespan, evolution, and longevity factors
Healthy Aging and Family Background
- David's father experiments on himself with NAD to age well
- David discusses his family history of early deaths and his grandmother's unconventional advice
- Grandmother's rebellious life and impactful advice on making the world a better place
Facing Climate Change and Longevity Benefits
- David's perspective on overcoming challenges like climate change
- Financial advantages of extending health and lifespan, and use in combating global issues
- Case study of David's father's transformed outlook and active lifestyle at 80
Goal Setting and Happiness
- Goal setting is crucial for human happiness and fulfillment
- Working towards goals and making progress leads to a sense of purpose
- People find satisfaction in accomplishments and purposeful tasks
Ageing, Health, and Biases
- Perception of age is changing, with 50 being considered relatively young and fit
- Discussion around overcoming biases against the elderly in society and healthcare
- Personal account of challenging biases in healthcare and making informed decisions for healthy ageing
Kevin Rose's Company and Apple Watch - Balancing Health and Technology
- Discussion about using body as a guide for health decisions at 50 years old
- Mention of using a ring called Aura to measure pulse and sleep
- Conversation about Kevin Rose's involvement in the company behind Aura and recommendation of dig.com for interesting stories and videos
NAD vs. NMN: The Debate on Health Supplements
- Comparison between the effects and methods of taking NMN and IV NAD supplements
- Mention of personal experimentation with IV NAD and discussion on its effectiveness
- Insight into the lack of conclusive evidence on the benefits of IV NAD and self-experimentation in the health field
Raw Milk Raid: Federal Agents Attack Tiny Buying Club
- In 2011, a small raw food club sharing raw milk was raided by federal agents.
- The raid was criticized as an attack on food freedom by targeting a harmless buying club.
- There were concerns raised about the focus on trivial food safety issues like raw milk rather than more significant concerns.
Healthy Eating Habits from France and Italy
- Discussion on the French and Italians and their healthier habits related to bread and fats.
- Insight into the beneficial effects of consuming bread with butter or olive oil.
- Explanation about the positive impact of consuming pasta in Italy and the difference in the effect on the body.
Resveratrol Experiment and Statins Debate
- Higher doses of resveratrol showed positive effects on mouse longevity and health
- Discussion on the use of statins despite potential negative effects
- Comparison with Anthony Bourdain's choices regarding statins and diet
Sleep, Alzheimer's & Prevention Strategies
- Importance of adequate sleep in relation to Alzheimer's disease
- Discussion on sleep aids like Ambien and melatonin
- Strategies to combat Seasonal Affective Disorder and maintaining overall well-being
NMN and Radiation Protection
- NMN can protect against the effects of radiation by boosting body's ability to prevent changes to the biological clock
- Potential use of NMN discussed with NASA for safe Mars travel
- Commercial availability of NMN mentioned without specific brand names
CRISPR: Gene Editing and Controversies
- CRISPR revolutionizing medicine by allowing targeted genetic alterations
- Discussion on Chinese experimentation with genetic alterations and HIV prevention
- Ethical and scientific concerns regarding gene editing in embryos raised
Rejuvenation Potential with Doxycycline: Restoring Vision in Mice
- The drug doxycycline can reprogram genes in mice leading to vision restoration
- Possibility of permanent rejuvenation indicated by cells regressing in age
- Future implications could include age reversal and rejuvenation with engineered children
Revolutionizing Medical Treatment: Vision and Injury Rejuvenation
- Entrepreneurial endeavor towards applying rejuvenation technology in medical treatment
- Exploration of rejuvenation for chronic diseases and injuries
- Promising results shown in rejuvenation of optic nerves leading to restored vision
Cam Haynes and Reprogramming: A Visionary Solution for Aging
- Discussion on the innovative reprogramming approach to aging, contrasting it with routine methods.
- Notable mention of Cam Haynes, aged 52, showcasing exceptional vision quality resembling that of a young person.
- Exploration of age-related macular degeneration and the intriguing aspects of the reprogramming technique.
Senolytics: Eradicating Zombie Cells for Youthful Regeneration
- Insights into senolytics, defining and targeting senescent cells in the aging process.
- Explanation of the detrimental effects of senescent cells and their potential role in aging and diseases like cancer.
- Discussion on rejuvenating tissues and reversing aging effects through senolytics, alongside promising advancements in clinical trials.