#994 - Dom D'Agostino

Episode Timestamps

• 00:00:00

  Jimmy and the Benefits of Ketogenic Wine: Exploring Health with Tim Ferriss

  • Jimmy discusses his experience on Tim Ferriss's podcast and the introduction of a specific wine that supports a ketogenic diet.
  • He highlights the implications of non-glycemic wine on blood glucose levels, enabling sustained ketosis.
  • The chapter mentions the role of ketogenic diets in managing health issues like epilepsy, referencing their historical application at institutions such as Johns Hopkins and Mayo Clinic.
• 00:02:12

  Innovations in Ketogenic Diets: From Pediatric Epilepsy to Canine Cancer Therapy

  • Jimmy explains the evolution of the ketogenic diet from its initial focus on pediatric epilepsy to broader applications including polycystic ovary syndrome and genetic disorders.
  • He discusses a conference dedicated to metabolic therapeutics featuring leading academics and their research on dietary impacts on health.
  • The chapter covers the keto pet sanctuary, which implements ketogenic diets for dogs with cancer, advocating for a raw food approach tailored for optimal health.
• 00:12:59

  Navy SEAL Researcher Dr. S. James on the Role of Ketogenic Diets in High-Pressure Environments

  • Dr. S. James turned to ketogenic diets during his neuroscientific research on seizures, particularly in Navy SEALs facing CNS oxygen toxicity.
  • He explored how ketones enhance brain energy production, facilitating resilience in extreme physiological conditions.
  • Research evolved into practical applications of ketogenic diets for epilepsy, specifically in scenarios where traditional drugs failed.
• 00:15:06

  Mike Dancer's Life-changing Encounter with Dr. S. James and Ketogenic Diet

  • Mike Dancer, a UK patient with terminal epilepsy, experienced life-altering results after following Dr. James' ketogenic diet guidance.
  • After previously failing over a dozen anti-epileptic medications, he found significant relief and improved body composition through the ketogenic regimen.
  • The story highlights the lack of infrastructure in healthcare for nutritional therapies and the under-utilization of ketogenic diets in medical treatments for seizures.
• 00:25:59

  Rob Wolf's Struggles with Ketogenic Diet While Training

  • Rob Wolf discusses his challenges maintaining a ketogenic diet during intense jujitsu training.
  • He considers incorporating slow carbs on high training days to improve performance.
  • Insights on metabolism and adaptation to different fuel sources highlight the complexity of dietary needs for athletes.
• 00:35:33

  Misconceptions and Scientific Insights on the Ketogenic Diet

  • The discussion emphasizes the misconceptions surrounding the ketogenic diet and its benefits.
  • Criticism from certain fitness trainers about the ketogenic diet lacks scientific backing.
  • Highlights the transition time needed for athletes to adapt to fat and ketone-based energy, noting that benefits manifest over months.
• 00:37:37

  Fighter's Transformation: The Impact of the Ketogenic Diet on Performance as Described by an Athlete

  • The athlete discusses rapid weight loss and performance changes due to adopting a ketogenic diet.
  • Experiences 'keto flu' and a significant change in energy levels during intense workouts.
  • Mentions the correlation between adherence to the diet and improved athletic performance over time.
• 00:39:48

  George K. Hill's Groundbreaking Study: Ketogenic Diet's Cognitive Benefits and Neurological Applications

  • Cognitive clarity and sustained energy levels reported by the speaker due to a ketogenic diet.
  • Highlights George K. Hill's 1967 study demonstrating the brain's ability to utilize ketones over glucose.
  • Explores potential therapeutic implications for neurological disorders and the role of ketone supplements.
• 00:50:14

  Cognitive Benefits of Exogenous Ketones: Insights from Key Genics and Proovit's Research

  • Discussion of Key Genics and Proovit's keto OS products, highlighting the importance of combining beta hydroxybutyrate with medium chain triglycerides for enhanced effects.
  • Research collaborations with government agencies, including the Department of Defense and NASA, to optimize ketone formulas for various health benefits like anti-seizure and motor function effects.
  • Personal anecdotes about dietary preferences, including the significance of sardines and eggs in the diet, and addressing concerns about heavy metals in fish consumption.
• 00:57:47

  Nutritional Deficiencies on the Ketogenic Diet: B12 and Magnesium Insights

  • Exploration of cardiovascular and neurological effects associated with high fish consumption, including mercury levels impacting health.
  • Discussion about potential deficiencies of B12 and magnesium in a ketogenic diet, with personal experience related to cramping and supplementation.
  • Insights on food sources of micronutrients, emphasizing the importance of sourcing quality products, like those from Butcher Box and Wild Planet.
• 01:00:00

  Dr. Vincent Tidoan's Neuroprotective ALS Protocols: Exploring Epsom Salts and Ketogenic Diet

  • Discussion on the benefits of Epsom salt baths for ALS patients to mitigate glutamate-induced neurotoxicity.
  • Introduction of Dr. Pasanetti's studies on ketogenic diets and medium-chain triglycerides for ALS with a focus on mouse model research.
  • Overview of the Diana Protocol developed by Dr. Vincent Tidoan, showcasing supplements that offered therapeutic effects for ALS patients.
• 01:30:00

  Unveiling Ketosis: How Ketone Supplements Can Transform Brain Energy Metabolism

  • Exploration of exogenous ketones as a potential energy source for the brain, surpassing glucose under specific conditions.
  • Discussion on the role of ketones in supporting brain function, especially in conditions like Alzheimer's and traumatic brain injury.
  • Insight into the sustained benefits of ketone metabolism as individuals age compared to the decline in glucose metabolism.
• 01:13:47

  Averta Health’s Revolutionary Approach to Reversing Type 2 Diabetes

  • Averta Health aims to reverse 100 million cases of type 2 diabetes within the next decade, addressing the massive financial burden of diabetes management.
  • Almost 90% of participants in Averta's program have successfully reduced or eliminated their insulin usage through carbohydrate restriction.
  • The chapter highlights the importance of adapting dietary approaches to manage carbohydrate intolerance effectively.
• 01:56:12

  Innovations in Ketogenic Diet for Health Optimization and Athletic Performance

  • The ketogenic diet is presented as a powerful alternative for controlling appetite and stabilizing blood glucose levels.
  • Athletes may benefit from ketogenic diets to enhance recovery and brain health, particularly in sports with a high risk of concussions.
  • Emerging technologies and apps are paving the way for better macro management and individual optimization of ketogenic dietary plans.
• 01:13:47

  Gary Taubes and Robb Wolf Discuss the Evolution of the Ketogenic Diet

  • Gary Taubes and Robb Wolf were featured speakers at the Low Carb USA conference, which highlighted advancements in the ketogenic diet.
  • The ketogenic diet is evolving from a treatment for pediatric epilepsy to a mainstream lifestyle for better health.
  • Using a ketogenic diet has helped the speaker achieve greater cognitive performance, leading to more productivity in their lab work.
• 01:56:12

  Research Findings: Exogenous Ketones and Anxiety Reduction in Seizure Disorders

  • The speaker's wife developed a program to analyze absence seizures, which often go unrecognized.
  • A study showed that exogenous ketones reduced anxiety behavior by 25-30% in rats when tested in elevated plus maze conditions.
  • The speaker shared their enthusiasm for how ketosis can calm anxieties, particularly before stressful activities such as bow hunting.
• 01:13:47

  Ken Ford's Innovative Keto Ice Cream at the Institute for Human and Machine Cognition

  • Ken Ford, director of the Institute for Human and Machine Cognition, promotes ketogenic diets for cognitive enhancement.
  • A James Beard award-winning chef at the institute develops innovative keto ice cream recipes, using MCT and stevia.
  • The chapter details the experience and testing of various keto-friendly foods, including keto brownies and shakes, emphasizing the importance of taste and dietary adherence.
• 01:56:12

  Deep Dixit’s Groundbreaking Research on Ketones and Their Health Benefits

  • Deep Dixit from Yale University studies the effects of ketones on health, highlighting their anti-inflammatory properties.
  • Ketones act as more than just an energy source; they also function as signaling molecules affecting inflammation pathways.
  • The discussion includes personal anecdotes about dietary experiences in Italy, emphasizing differences in food quality and processing, particularly heirloom grains.
• 01:07:43

  Dr. Andrew H. K. F. G. discusses Ketogenic Diet Benefits for Cancer Patients with Max Love Project

  • Dr. Andrew H. K. F. G. emphasizes the importance of a ketogenic diet for individuals battling systemic chronic inflammation as they age.
  • The discussion covers the case of Max Love, a child with a brain tumor, and the effectiveness of combining the ketogenic diet with conventional cancer therapies.
  • Dr. Andrew advocates for using the ketogenic diet as an adjunct therapy to enhance standard cancer treatments and improve patient recovery.
• 01:16:21

  Innovative Cancer Treatments: Dr. Andrew H. K. F. G. Explores Ketogenic Diet and Hyperbaric Oxygen Therapy

  • Dr. Andrew presents groundbreaking research on the combined use of ketogenic diets with hyperbaric oxygen therapy for cancer treatment.
  • He shares insights about how increasing oxygen in damaged cancer cells can induce cell death while protecting healthy cells.
  • The conversation reveals a growing interest in using metabolic therapies in cancer research, alongside traditional treatments, to improve patient quality of life.
• 01:13:47

  Dr. Adrian Check's Revolutionary Approach to Ketogenic Diets at Barrow Neurological Institute

  • Dr. Adrian Check highlights the impact of ketogenic diets on various medical conditions beyond pediatric epilepsy.
  • Dr. Eric Kosoff from Johns Hopkins is mentioned as an influential figure contributing to the application of ketosis in medical studies.
  • Recent findings reveal significant benefits of ketosis for managing viral disorders and enhancing wound healing.
• 01:56:12

  Innovative Wound Healing Research by Dr. Shannon Kessel and the Epigenics Foundation

  • Dr. Shannon Kessel's PhD research demonstrates that ketones significantly improve wound healing in ischemic and aging models.
  • Research findings suggest a 20-25% increase in wound healing time through enhanced blood flow and reduced inflammation.
  • Research collaborations with Dr. Lisa Gould and other institutions emphasize the necessity for further funding to advance these groundbreaking studies.
• 01:13:47

  Dr. Dorian Yates' Fasting Experiment: Transforming Body and Mind

  • Dr. Dorian Yates shares his experience of a seven-day fast, highlighting significant improvements in mental clarity and productivity.
  • During the fast, he experienced a rapid weight loss of eight to nine pounds, followed by a return to his normal weight.
  • His fasting journey, inspired by Harvard's George Cahill study, aimed to break free from the obsession with eating and help mentally reset.
• 01:56:12

  The Remarkable Case of a 382-Day Fast: A Deep Dive into Metabolic Health

  • Rob Wolf discusses the extraordinary case of a man who fasted for 382 days, shedding over 275 pounds while maintaining skin elasticity.
  • The conversation covers the profound metabolic benefits of fasting, particularly in relation to cancer cell pathology and autophagy.
  • Dr. Yates and Wolf highlight the increasing acceptance of fasting and ketogenic diets in medical communities, despite prior skepticism.
• 01:13:47

  Ronda Patrick and the Power of Ketogenic Intermittent Fasting

  • Discussion on the benefits of reducing carbohydrate intake for older athletes and their adaptation during off-season training.
  • Explanation of ketogenic intermittent fasting as advocated by Dr. Ronda Patrick, emphasizing time-restricted eating.
  • Insights on achieving ketosis through careful macro-calculation and the use of MCTs, with potential health benefits highlighted.
• 01:56:12

  Jeff Volek's Research Transforming Athletic Performance with Ketosis

  • Jeff Volek's studies from Ohio State University demonstrating significant fat oxidation rates in athletes on a well-formulated ketogenic diet.
  • Introduction of the Keto technology company focused on optimizing supplements for performance enhancement, as well as ongoing human studies.
  • Elena Gross's pioneering research on ketone salts for migraine treatment, stemming from her personal battle with cluster headaches.
• 01:57:04

  Dr. Don Kurnagas and the Role of Ketogenic Diet on Migraines and Autism Treatment

  • Discussion on the effectiveness of ketogenic diets and ketone supplementation for migraine relief, especially linked to neuroinflammation.
  • Dr. Don Kurnagas emphasizes the challenges and possibilities of a vegan ketogenic diet, highlighting the importance of specific dietary formulations.
  • A case report is mentioned where a mother put her autistic child on a ketogenic diet, resulting in significant improvements and documented remission.
• 02:23:18

  Exploring Cancer Treatment: Insights from Dr. Thomas Saferd on Metabolic Diseases

  • Dr. Thomas Saferd advocates for viewing cancer as a metabolic disease, incorporating ketogenic diet principles in treatment and prevention strategies.
  • The potential of combining ketogenic diet therapies with CBD oil for reducing inflammation and enhancing patient health post-treatment is discussed.
  • Current advancements in cancer research are shared, showing a shift towards targeting cancer metabolism and developing metabolic therapy clinics.
• 01:13:47

  Innovative Uses of the Ketogenic Diet: Insights from the Max Love Project and Verda Health

  • The Max Love Project aids families with children suffering from cancer through ketogenic diet applications.
  • Verda Health is ambitious in its goal to reverse type 2 diabetes in up to 100 million people within the next decade.
  • Resources such as keto nutrition dot org provide a wealth of information, including recipes and dietary guidance for various health issues.
• 01:56:12

  Hollywood's Influence: Jim Abrams and the Charlie Foundation's Push for Ketogenic Diets

  • Jim Abrams, a Hollywood producer, played a pivotal role in popularizing the ketogenic diet through the Charlie Foundation.
  • The movie 'First Do No Harm,' starring Meryl Streep, raised awareness about the ketogenic diet's benefits.
  • The speaker expresses gratitude for the chance to work in a research field that aligns with enhancing health and wellness using ketogenic principles.