#1176 - Dom D'Agostino & Layne Norton
NaN minutesEpisode #1176
Dom D’Agostino, Ph.D., is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). Layne Norton is a renowned prep/physique coach and pro-natural bodybuilder/powerlifter with a PhD in Nutritional Sciences.
Episodes with Dom D'Agostino
Watch the full episode of #1176 - Dom D'Agostino & Layne Norton.
Episode Timestamps
Layne Norton - From Powerlifting to Nutrition Science
- Layne Norton's background in bodybuilding, powerlifting, and nutritional science.
- Discussion on the challenges of navigating nutrition information and misinformation.
- Meeting and friendship with Dom D'Agostino through bodybuilding forums.
Dom D'Agostino - The Science Behind Ketogenic Diet for Military Personnel
- Dom D'Agostino's transition from neuroscience to studying ketogenic diet impact on military personnel.
- Research on the benefits of the ketogenic diet for managing epilepsy and preventing seizures.
- Focus on developing ketogenic strategies for enhancing military readiness and performance.
Metabolic Effects of Accumulating Byproducts
- Insufficient cell flexing leads to accumulation of metabolic byproducts.
- Accumulation inhibits crucial cellular processes like the Krebs cycle and glycolysis.
- Results in insulin receptor inhibition, causing an overflow of glucose, fatty acids, and amino acids in type two diabetes.
Dietary Strategies and Weight Management
- Obesity and type two diabetes stem from overfeeding and underactivity.
- Sustainability key to weight loss success, with most diets having high failure rates.
- Individual response crucial in choosing between high carb, low carb, or ketogenic diets for lasting weight management.
Effect of Ketogenic Diet on Fat Loss and Muscle Retention
- Protein in ketogenic diets has a thermogenic and appetite suppression effect
- Calories and protein equated in studies show no difference in fat loss
- Protein aids in weight loss, thermogenesis, and lean body mass retention
Diet Flexibility and Health Benefits
- Losing 10% of body weight provides significant health benefits
- Adherence to diet is crucial for overall health improvement
- Individual preferences and sustainability of diet play a key role in successful weight loss
Investigating Sugar and Obesity Correlation
- Evidence of sugar intake increase along with obesity until the mid-90s
- Shift in sugar consumption trends while obesity rates continued to rise
- Discussion on overall calorie intake's correlation with obesity rates
Comparing Sugar and High Fructose Corn Syrup
- Analysis of sugar sucrose versus high fructose corn syrup composition
- Impact of surplus fructose intake on obesity and health
- Highlight on obesity rise due to excess calorie consumption
Discussion on Type One Diabetes - Andrew Kutnik
- Andrew Kutnik, a type one diabetic, benefited from low carb and DEXCOM monitoring system
- Tighter control of glucose and insulin levels can extend lifespan in type one diabetics
- Studies on BMI vs. insulin levels highlight the impact on health and metabolic syndromes
Impact of Insulin and Diets on Health
- Obese individuals may have elevated insulin levels but not necessarily more body fat
- Meta-analysis shows balance between BMI, post-prandial insulin, and obesity
- Comparative analysis of higher vs lower carb diets and health outcomes
Metabolic Effects of Dieting and Rapid Weight Changes
- When dieting, metabolic rate slows down to adapt to lower food intake
- Reversing the slowed metabolism after a long dieting period takes time
- Significant impact observed on metabolic rate and fat storage in biggest loser participants
Efficiency and Metabolic Adaptation
- Body adapts to lower energy intake by becoming more efficient
- Components of total daily energy expenditure and their changes during dieting
- Increase in fat cell number post-diet if overfeeding is done rapidly
Study by Tom Safer Reveals Impact of Ketogenic Diet on Cancer Growth
- Mentor Tom Safer publishes study showing unrestricted ketogenic diet promoting cancer growth in brain tumor model
- Experiment involved feeding mice sugary ketogenic formula leading to metabolic abnormalities
- Discussion on fat acceptance and health implications of obesity
Journey of Bodybuilders and Impact of Extreme Dieting
- Exploration of bodybuilders' extreme dieting impacting hormone levels and mental health
- Discussion on metabolic adaptation, self-defense system, and hypo-gonadal effects
- Importance of sustainable dietary practices and risks of yo-yo dieting in physique sports
Discussion on Women's Health and Dietary Sustainability
- Women's health considerations, including menstrual cycle implications and body fat management
- Critique of paleo diets and their evolutionary validation
- Emphasis on sustainability and gradual dietary improvements
Debunking Dietary Myths and Individual Sensitivities
- Debate on dairy consumption and its health effects
- Insights into protein sensitivities and immune responses
- Discussions on lactose intolerance and individual dietary variations
Debunking Dietary Myths and Advocating for Comprehensive Data
- Emphasizing the importance of presenting all data to avoid cherry-picking.
- Discussing the reliability of animal studies compared to human studies in regards to diet.
- Highlighting the complexity of finding a universal 'perfect' diet and the need for individualized approaches based on health conditions.
The Crucial Role of Physical Activity and Body Composition in Longevity
- Stressing the significance of weightlifting and muscle mass for overall health benefits.
- Addressing the impact of body composition on life expectancy and the importance of weight control.
- Advocating for a balanced diet coupled with physical activity as key factors in maintaining health.
Discussion on Effects of Food on Training Performance
- Different perspectives on the impact of meal size and timing on training performance.
- Anecdote shared about jiu-jitsu training and meal consumption.
- Emphasis on the psychological aspect of feeling fueled for training.
Debunking Myths and Exploring Psychological Influence on Health
- Discussion on the placebo effect and mind-body connection in health outcomes.
- Importance of belief and faith in achieving therapeutic results.
- Emphasis on brain's role in controlling physiological processes and immune system.
Ketone Measurement Methods
- Blood, breath, and urine are methods to measure ketones.
- Keto mojo and Abbott Labs products popular for blood ketone measurements.
- Urine strips initially effective but less reliable over time.
Intermittent Fasting and Autophagy
- Intermittent fasting impacts autophagy and inflammation.
- Carefully balancing meals crucial in intermittent fasting.
- No significant difference in fat loss between intermittent fasting and regular caloric intake over 24 hours.
Discussion on Carnivore Diet with Potential for Weight Loss Benefits
- Exploration of the benefits of a strict carnivore diet
- Observation of positive effects on individuals with weight loss goals
- Emphasis on the need for long-term studies and medical supervision
Debate on Ketogenic Diet and its Impact on Health
- Analysis of the metabolic benefits of a ketogenic diet
- Cautionary note on ketogenic diet for type one diabetics
- Discussion on the controversy surrounding the diet and insulin levels
Maximizing Gym Performance as a Type One Diabetic
- Learning to adjust protein intake for body composition alterations and performance gains
- Transitioning to a low carb diet to reduce blood glucose fluctuations and insulin requirements
- Importance of diet adherence in managing blood glucose levels
Ketogenic Diet Preferences and Adherence
- Customizing diets based on preferences and metabolic rates
- Balancing fat and carb restrictions for optimal hormone levels
- Challenges of adherence and reward mechanisms post-dieting phases
Analysis of behaviors contributing to weight loss success
- Weight loss success is achieved through various methods and behaviors.
- Key behaviors include regular self-weighing, practicing cognitive restraint, and consistent exercise.
- Behavioral changes are pivotal for sustainable weight loss success.
Importance of Discipline and Goal-setting in Achieving Success
- Success is built through discipline and achieving incremental goals.
- Building confidence involves setting and attaining goals consistently.
- Long-term success is a result of years of achieving smaller goals, leading to bigger accomplishments.
Zach Bitter: Record-Breaking Runner and Ketogenic Diet Enthusiast
- Zach Bitter holds the American record for the fastest 100 mile run in 11 hours and 40 minutes.
- He follows a ketogenic diet and takes in glucose during long races.
- Glucose is considered a powerful performance-enhancing substance, especially in endurance events.
Nutritional Strategies for Endurance and Recovery
- Small, consistent glucose intake during races is more effective than bulk consumption for carb-adapted individuals.
- Ketone supplements, alongside glucose intake, can benefit anaerobic performance.
- Optimal recovery involves leveraging various fuel sources like fats, carbohydrates, and ketones.
Ketogenic Diet Study on Athletes
- Recent study compared ketogenic vs. non-ketogenic diet in weightlifters
- Outcome showed slightly less muscle mass with ketogenic diet despite equating protein intake
- Discussion on resistance training and MMA fighters in relation to inflammation and performance
Autophagy, Muscle Mass, and Performance
- Autophagy's role in protein degradation and potential impact on muscle mass
- Discussion on the balance between muscle mass, health, and individual goals
- Importance of considering individual context in relation to diet and performance
Cancer Research Data Integrity
- Issues in cancer research data replication
- Motivations behind misleading data: money, power, ego
- Importance of controlled, blinded research for data accuracy
Conspiracy Theories and Research Ethics
- Addressing conspiracy theories in scientific research
- Challenges in trust and credibility of scientists
- Emphasis on transparency, bias acknowledgment, and vetting sources